The 16th century is a one-hundred-year period of time, which began in 1501 and ended in 1600.
American Horror Story

1500s
- An English Druid girl named Scathatch stows away aboard a vessel bound for the new world. The journey is wrought with great misfortune. The sailors believe that the presence of a woman aboard their ship angered the sea gods. They attempt to burn her at the stake as a witch, but Scathatch escapes into the wild. (AHS: Chapter 4)
1566
- June 19th: James VI is born in Edinburgh Castle in Scotland. He will one day become the King of England and the King of Scotland.
1587
- All of the colonists from Roanoke Colony in North Carolina mysteriously disappear without a trace. What happened them will become one of the great mysteries of the 20th and 21st centuries. (Historical record)
- The Druid witch Scathatch recruits Tomasyn White to be her instrument of evil. Tomasyn tracks the members of the Roanoke colony to their new home and slaughters them. She offers up a young girl named Priscilla as a blood sacrifice. She then offers herself to Scathatch who slits her throat. The blood of the colonists mingles with the soil of the land, consecrating it. The spirits of all who die in this area are now bound to the land. (AHS: Chapter 4)